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IONS reported Third Quarter 2026 results. The stock moved -21.4% on the print.
IONSearnings

Ionis Pharmaceuticals, Inc. (IONS) Q3 FY2026 earnings

November 9, 2026 · SharpeIQ Research Desk

Reported results

  • GAAP total revenue was $243 million for the third quarter of 2026.
  • GAAP operating expenses were $373 million for the third quarter of 2026.
  • Operating expenses on a non-GAAP basis were $330 million for the third quarter of 2026.
  • GAAP loss from operations was $130 million for the third quarter of 2026.
  • Loss from operations on a non-GAAP basis was $87 million for the third quarter of 2026.
  • Cash, cash equivalents and short-term investments were $1.9 billion as of September 30, 2026.

Guidance

  • Full year 2026 total revenue guidance is $875-900 million.
  • Full year 2026 TRYNGOLZA net product sales guidance was lowered to approximately $50 million.
  • Full year 2026 DAWNZERA net product sales guidance is $110-120 million.
  • Full year 2026 operating loss on a non-GAAP basis guidance is $425-475 million.
  • Full year 2026 cash, cash equivalents and short-term investments guidance is >$1.6 billion.

Price and volatility reaction

The stock moved -21.4% on the print. No front-expiry chain was on file, so there is no straddle expected move. 30-day ATM implied volatility moved -9.1 vol points across the event (constant-maturity series — not the front-week crush).

MeasureValueBasis
Close before release39.422026-11-06
Close after release312026-11-09
Realised move-21.4%close to close
30d ATM IV change-9.1 vol ptsconstant-maturity series, not the front expiry
Price and volatility reaction. Closes either side of the release. No front-expiry chain on file for a straddle expected move. SharpeIQ — listed option chain and price_history

Source

The figures above come from the earnings release the company filed with the SEC on 2026-11-09 (8-K, Item 2.02). Read the original filing on sec.gov.

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